Coherence in observational studies.

P R Rosenbaum

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PubMed · 8068837

Coherence in observational studies.

P R Rosenbaum

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Abstract

It is often said that the coherence of an association between a treatment and outcomes is important in judging whether the association is causal. An attempt is made to quantify the evidence provided by a coherent association. This is done in two steps. First, a test is developed to detect a coherent association. The test is a generalization of the tests of Mann and Whitney, Wilcoxon, and Gehan. Second, the sensitivity of the test to hidden bias is examined. The question is whether a coherent pattern of associations implies less sensitivity to hidden biases. An example is considered in detail.

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P R Rosenbaum. 1994. Coherence in observational studies.. https://pubmed.ncbi.nlm.nih.gov/8068837/

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