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On allele frequency computation from DNA typing data.

R Chakraborty·L Jin·Y Zhong·M R Srinivasan·B Budowle
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Abstract

Forensic applications of DNA typing data require the estimation of the frequencies of all observed alleles, which is currently done by a fixed set of groupings (binning) of alleles in a database. Recently it's validity has been questioned on the ground that when a DNA fragment size is close to a bin boundary, the frequencies of all adjacent bins should be added. On the contrary, the current forensic database indicates that when the match window of a DNA fragment overlaps 2 bins, it is enough to consider the bin with the larger frequency, and this never underestimates the frequency within the match interval with the current choice of fixed-bin widths. On average, the current fixed-bin procedure yields an allele frequency at least 2-fold higher than that of a floating-bin.

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AllelesBloodChromosome MappingCross-Cultural ComparisonDNAFemaleForensic MedicineGene FrequencyHumansInformation SystemsMalePolymorphism, Restriction Fragment LengthVaginaComparative StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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R Chakraborty, L Jin, Y Zhong, M R Srinivasan, B Budowle. 1993. On allele frequency computation from DNA typing data.. https://doi.org/10.1007/bf01225049

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