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PubMed · 8140076

Hypoglycaemia-induced ischaemic ECG changes.

A Markel·S Keidar·K Yasin
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Abstract

A patient with an 8 year history of insulin-dependent diabetes mellitus was admitted to the emergency ward for hypoglycaemic coma (blood glucose 1.11 mmol/l). The initial electrocardiogram revealed a junctional rhythm and major ischaemia with an ST depression of 6-7 mm. Sinus rhythm and normal repolarization were recovered 15 minutes after administration of 50% glucose. No evidence of myocardial infarction appeared during follow-up. Such hypoglycaemia-induced ECG changes have rarely been documented and no conclusive explanation has been put forward although altered balance between energy supply and demand in myocardial tissue has been suggested. Special care should be taken when administering hypoglycaemic agents to patients at risk for myocardial ischaemia.

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Diabetes Mellitus, Type 1ElectrocardiographyGlucose Solution, HypertonicHumansHypoglycemiaMaleMiddle AgedMyocardial IschemiaCase ReportsJournal Article

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BibTeXRIS

A Markel, S Keidar, K Yasin. 1994-01-22. Hypoglycaemia-induced ischaemic ECG changes.. https://pubmed.ncbi.nlm.nih.gov/8140076/

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Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial.

BACKGROUND: Recently, high prevalence of exocrine dysfunction in diabetic populations has been reported. Patients with fecal elastase 1 concentration (FEC) <100 microg/g have also been demonstrated to suffer from steatorrhea in about 60% of cases, indicating the need of pancreatic enzyme replacement therapy. Until now, there have only been a few reports on the use of enzyme replacement therapy in diabetic patients with exocrine pancreatic insufficiency. This investigation was designed to evaluate the impact of enzyme-replacement therapy on glucose metabolism and diabetes treatment in a prospective study of insulin-treated patients with diabetes mellitus. METHODS: A total of 546 patients with diabetes mellitus requiring insulin treatment were screened for exocrine dysfunction by FEC measurements. One hundred and fifteen patients (21.1%) had FEC <100 microg/g (normal >200 microg/g). Of these, 95 patients entered the study and 80 patients were randomized to receive either pancreatin (Creon) (39 patients) or placebo (41 patients) in a double-blind manner. Parameters of glucose metabolism, diabetes therapy and clinical symptoms were recorded in standardized protocols for 16 weeks. RESULTS: During the observation phase of 16 weeks, there were no significant differences between both groups concerning HbA(1c), fasting glucose levels, 2-h pp glucose levels, clinical parameters and safety parameters. A reduction in mild and moderate hypoglycemia was observed in the pancreatin group at the end of the study. CONCLUSIONS: Pancreatin therapy can be used safely in patients with diabetes mellitus and exocrine dysfunction. Parameters of glucose metabolism were not improved by enzyme replacement therapy.

Diabetes Mellitus, Type 1↗