PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 8365035

Cicatricial pemphigoid.

D F Mutasim·N J Pelc·G J Anhalt
View original source ↗Export metadata ↓

Abstract

Cicatricial pemphigoid presents with oral or ocular inflammation and blisters that are followed by scarring. The differential diagnosis of cicatricial mucositis includes other subepithelial blistering disorders. The disease is usually chronic and can be associated with high morbidity. Treatment of severe cases with immunosuppressive agents is usually helpful.

Explore related subjects

Fluorescent Antibody TechniqueHumansMicroscopy, ImmunoelectronMucous MembranePemphigoid, Benign Mucous MembraneSkinJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D F Mutasim, N J Pelc, G J Anhalt. 1993. Cicatricial pemphigoid.. https://pubmed.ncbi.nlm.nih.gov/8365035/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

The use of siRNA to validate immunofluorescence studies.

Cellular immunofluorescence studies can be validated by using either specific small interfering RNA (siRNA) duplexes or expression plasmids that induce the expression of specific siRNAs. The usage of either siRNA tool reduces the expression of the specific protein being studied, thus reducing substantially or abolishing the immunofluorescence detected when using a fluorescent antibody that recognizes the protein.

Fluorescent Antibody Technique↗
PubMed2006

Translational diffusion of fluorescent proteins by molecular fourier imaging correlation spectroscopy.

The ability to noninvasively observe translational diffusion of proteins and protein complexes is important to many biophysical problems. We report high signal/noise (>or=250) measurements of the translational diffusion in viscous solution of the fluorescent protein, DsRed. This is carried out using a new technique: molecular Fourier imaging correlation spectroscopy (M-FICS). M-FICS is an interferometric method that detects a collective Fourier component of the fluctuating density of a small population of fluorescent molecules, and provides information about the distribution of molecular diffusivities. A theoretical analysis is presented that expresses the detected signal fluctuations in terms of the relevant time-correlation functions for molecular translational diffusion. Furthermore, the role played by optical orientational degrees of freedom is established. We report Fickian self-diffusion of the DsRed tetramer at short timescales. The long-time deviation of our data from Fickian behavior is used to determine the variance of the distribution of the protein self-diffusion coefficient. We compare our results to the expected outcomes for 1), a bi-disperse distribution of protein species, and 2), dynamic disorder of the host solvent.

Fluorescent Antibody Technique↗