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PubMed · 853335

Vitamin E deficiency and enhanced platelet function: reversal following E supplementation.

A M Lake·M J Stuart·F A Oski
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Abstract

Marked platelet hyperaggregability to adenosine diphosphate, epinephrine, and collagen was demonstrated in two children with vitamin E deficiency, with complete reversal following E supplementation. No clinical thrombotic tendency was observed during the E-deficient state. The action of vitamin E in the schema of platelet arachidonate peroxidation appears to be at the step of phosphilpase A activation, or the conversion of arachidonic acid into the cyclic endoperoxides, since the peroxidation product malonaldehyde was increased during the E-deficient state with normalization following E sufficiency.

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Adenosine DiphosphateArachidonic AcidsBlood PlateletsCollagenEnzyme ActivationEpinephrineFemaleHumansInfantPhospholipasesPlatelet AggregationVitamin D DeficiencyVitamin ECase ReportsJournal Article

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A M Lake, M J Stuart, F A Oski. 1977. Vitamin E deficiency and enhanced platelet function: reversal following E supplementation.. https://doi.org/10.1016/s0022-3476(77)81235-3

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