Binocularity in prism-reared monkeys.

M L Crawford; R S Harwerth; Y M Chino; E L Smith

doi:10.1038/eye.1996.41

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PubMed · 8776443

Binocularity in prism-reared monkeys.

M L Crawford·R S Harwerth·Y M Chino·E L Smith

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Abstract

Prismatic binocular dissociation in infant monkeys mimicked a concomitant squint. Within 3 weeks, the numbers of binocular neurons in the primary visual cortex were reduced by half and did not recover with up to 5 years of subsequent unrestricted binocular visual experience. The monkeys failed to show binocular summation for spatial contrast sensitivity tasks and were unable to utilise horizontal binocular disparities in random-dot stereograms-two indices of stereoblindness. Electrophysiological analysis of the V1 and V2 cortices showed a dramatic reduction in binocular neurons. Analysis of interocular spatial phase tuning functions showed a conspicuous loss of excitatory binocular drive in V1 neurons which was sufficient to account for many of the defects in binocular function.

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Animals Depth Perception Disease Models, Animal Macaca Neurons Strabismus Vision, Binocular Visual Cortex Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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M L Crawford, R S Harwerth, Y M Chino, E L Smith. 1996. Binocularity in prism-reared monkeys.. https://doi.org/10.1038/eye.1996.41

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