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PubMed · 9086589

A sensitive method for evaluating condoms as virus barriers.

C D Lytle·J E Duff·B Fleharty·R L Bidinger·W H Cyr·L B Routson
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Abstract

A standard test is needed to evaluate condoms as barriers against sexually transmitted diseases, particularly those caused by viruses. The proposed method presented here consists of a previously published simple method using physiologic-based conditions plus improvements to increase test sensitivity and decrease confounding factors such as contamination. Limitations of the method were determined by measuring virus penetration through small, well-defined holes. The method can detect penetration of 2 nL (2 x 10(-6) mL) of challenge virus suspension as well as a hole of 2 microns diameter in a latex condom. The data also indicated that virus penetration of latex condoms occurred quickly, and the hole was then apparently closed or blocked.

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Bacteriophage phi X 174CondomsKineticsLatexPorositySexually Transmitted Diseases, ViralVirusesAmericasBarrier MethodsCondomContraceptionContraceptive EffectivenessContraceptive MethodsDeveloped CountriesDiseasesFamily PlanningGovernment AgenciesInfectionsMarylandNorth AmericaNorthern AmericaOrganizationsReproductive Tract InfectionsResearch ReportSexually Transmitted Diseases--prevention and controlTheoretical EffectivenessUnited StatesUsfdaUsphsJournal Article

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C D Lytle, J E Duff, B Fleharty, R L Bidinger, W H Cyr, L B Routson. A sensitive method for evaluating condoms as virus barriers.. https://pubmed.ncbi.nlm.nih.gov/9086589/

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