Serum complement sensitivity as a key factor in Lyme disease ecology.

K Kurtenbach; H S Sewell; N H Ogden; S E Randolph; P A Nuttall

doi:10.1128/iai.66.3.1248-1251.1998

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Serum complement sensitivity as a key factor in Lyme disease ecology.

K Kurtenbach·H S Sewell·N H Ogden·S E Randolph·P A Nuttall

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Abstract

The sensitivity of Borrelia burgdorferi sensu lato to animal sera was analyzed. Complement-mediated borreliacidal effects were observed with particular combinations of host serum and Borrelia genospecies. The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu lato, suggesting a key role of complement in the global ecology of Lyme borreliosis.

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Animals Bacteriolysis Complement System Proteins Cricetinae Ecology Humans Lyme Disease Mesocricetus Mice Mice, Inbred BALB C Muridae Species Specificity Journal Article

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K Kurtenbach, H S Sewell, N H Ogden, S E Randolph, P A Nuttall. 1998. Serum complement sensitivity as a key factor in Lyme disease ecology.. https://doi.org/10.1128/iai.66.3.1248-1251.1998

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