PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 9614524

Bilateral Kimura's disease with devastating visual outcome.

I Moroz·N Rosen·M Rosner
View original source ↗Export metadata ↓

Abstract

Kimura's disease is a chronic inflammatory disease involving connective tissues. We treated a patient with bilateral periocular Kimura's disease causing eyelid deformity and exophthalmos for over 20 years. She has been operated on 23 times and biopsies were taken and studied histologically. The disease continued despite the multiple surgical excisions. The consequent exophthalmos and lid changes caused lagophthalmos that resulted in severe visual impairment due to chronic bilateral corneal exposure. Kimura's disease may have a devastating effect on visual function.

Explore related subjects

Angiolymphoid Hyperplasia with EosinophiliaExophthalmosEyelid DiseasesFemaleHumansKeratitisMiddle AgedReoperationCase ReportsJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

I Moroz, N Rosen, M Rosner. 1998. Bilateral Kimura's disease with devastating visual outcome.. https://doi.org/10.1038/eye.1998.16

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

Synchronous unilateral renal cell carcinoma and Kimura disease of the kidney.

Kimura disease (KD) is a rare, benign, chronic inflammatory disorder most often found in young Asian males that can simulate a neoplasm. We report a case of renal cell carcinoma and KD within the same kidney. To our knowledge, this is the first reported case of KD involving the kidney confirmed pathologically, as well as the first association of KD with renal cell carcinoma.

Angiolymphoid Hyperplasia with Eosinophilia↗
PubMed2006

Combined treatment of steroids and cyclosporine in Kimura disease.

Kimura disease is a rare but distinctive chronic eosinophilic inflammatory disorder that is characterized by tumor-like lesions in the soft tissue and lymph nodes of the head and neck or parotid gland. Recently, many immunopathogenetic features of underlying T lymphocytes and related cytokines have been noted in Kimura disease. However, few previous studies have investigated the serial levels of cytokines in children. In this report we describe an 11-year-old Japanese boy with relapsing Kimura disease. Before the diagnosis of Kimura disease, the patient had a swelling on his left neck. Steroids were effective, but the tumor relapsed within a few months as the steroids were tapered. He was treated with steroids and cyclosporine. This treatment was done by measuring serial levels of serum soluble interleukin-2 receptor, interleukin-4, interleukin-5, and eosinophil cationic protein. These results suggest the activation of T-helper cells and T-helper 2 cytokines, that after activated B cells and eosinophilic infiltration play an important role in Kimura disease, and that cyclosporine suppresses the activity of this disease.

Angiolymphoid Hyperplasia with Eosinophilia↗
PubMed2006

Kimura's disease with generalized lymphadenopathy demonstrated by positron emission tomography scan.

Kimura's disease is a chronic inflammatory disorder that occurs mainly in Asian patients. Most imaging studies focus on the loco-regional involvement of this disorder. Images of the whole body fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) scan have not been reported in the literature before. The possibility of lymphoid clonality is also discussed frequently despite its clinically benign course. We present a patient of Kimura's disease initially assessed by whole body 18F-FDG PET study and proved by pathologic findings. 18F-FDG-PET scan showed diffusely intense uptake in the neck, axillary, pelvic and inguinal nodal regions bilaterally, as well as in the mediastinal, celiac region. The flow cytometric analysis of lymph node tissue confirmed the absence of clonality. The image of 18F-FDG-PET in Kimura's disease can closely resemble that seen in neoplastic disorders such as lymphoma or metastatic lymphadenopathy. It should be taken into consideration as a differential diagnosis for a generalized lymphadenopathy.

Angiolymphoid Hyperplasia with Eosinophilia↗