Cytotoxic quassinoids from Simaba cedron.

A Ozeki; Y Hitotsuyanagi; E Hashimoto; H Itokawa; K Takeya; S de Mello Alves

doi:10.1021/np980023f

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Cytotoxic quassinoids from Simaba cedron.

A Ozeki·Y Hitotsuyanagi·E Hashimoto·H Itokawa·K Takeya·S de Mello Alves

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Abstract

Four new quassinoids, cedronolactones A-D (1-4), together with nine known compounds, simalikalactone D (5), chaparrinone (6), chaparrin (7), glaucarubolone (8), glaucarubol (9), samaderine Z (10), guanepolide (11), ailanquassin A (12), and polyandrol (13), were isolated from the wood of Simaba cedron. The chemical structures of 1-4 were elucidated on the basis of their chemical and spectral properties. Cedronolactone A (1) was shown to exhibit a significant in vitro cytotoxicity (IC50 0.0074 microg/mL) against P-388 cells.

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Alkaloids Animals Antineoplastic Agents, Phytogenic Drug Screening Assays, Antitumor Humans Lactones Magnetic Resonance Spectroscopy Mass Spectrometry Mice Plant Extracts Plants, Medicinal Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Tumor Cells, Cultured Wood Journal Article Research Support, Non-U.S. Gov't

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A Ozeki, Y Hitotsuyanagi, E Hashimoto, H Itokawa, K Takeya, S de Mello Alves. 1998-06-26. Cytotoxic quassinoids from Simaba cedron.. https://doi.org/10.1021/np980023f

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