Liposome-DNA interaction: microcalorimetric study.

G M Mrevlishvili; B I Kankia; T J Mdzinarashvili; T I Brelidze; M M Khvedelidze; N O Metreveli; G Z Razmadze

doi:10.1016/s0009-3084(98)00019-x

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Liposome-DNA interaction: microcalorimetric study.

G M Mrevlishvili·B I Kankia·T J Mdzinarashvili·T I Brelidze·M M Khvedelidze·N O Metreveli·G Z Razmadze

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Abstract

The authors applied differential scanning calorimetry (DSC) for studying the thermodynamic characteristics of DNA-liposome interactions. At the first stage, the melting curves of the 'order-disorder' thermal transition for lipid component and of the 'helix-coil' transition for DNA were obtained. At the second stage, the phase behavior of the DNA-lipid mixture as a function of both components (lipid/DNA ratio) was obtained. The liposome-DNA interaction was investigated comparing the melting curves of the pure components and the mixture.

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Calorimetry, Differential Scanning DNA Dimyristoylphosphatidylcholine Liposomes Nucleic Acid Conformation Thermodynamics Journal Article Research Support, Non-U.S. Gov't

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G M Mrevlishvili, B I Kankia, T J Mdzinarashvili, T I Brelidze, M M Khvedelidze, N O Metreveli, G Z Razmadze. 1998. Liposome-DNA interaction: microcalorimetric study.. https://doi.org/10.1016/s0009-3084(98)00019-x

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