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Hydroxypropyl-beta-cyclodextrin and its combination with hydroxypropyl-methylcellulose increases aqueous solubility of delta9-tetrahydrocannabinol.

P Jarho·D W Pate·R Brenneisen·T Järvinen
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Abstract

Delta9-tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L. and its therapeutic effects are currently under intensive study. However, THC has a very low aqueous solubility (1-2 microg/mL), which restricts its use as a pharmaceutical. The present study demonstrates that THC forms a drug-cyclodextrin complex in an aqueous solution of hydroxypropyl-beta-cyclodextrin (HP-beta-CD), resulting in a thousand-fold increase in THC solubility. This improvement in solubility can be further increased by adding 0.1% hydroxypropylmethylcellulose to the HP-beta-CD solution. The present results suggest that the use of cyclodextrins might be a simple and useful method to overcome the poor water solubility of THC.

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2-Hydroxypropyl-beta-cyclodextrinCyclodextrinsDronabinolHypromellose DerivativesMethylcelluloseSolubilitybeta-CyclodextrinsJournal ArticleResearch Support, Non-U.S. Gov't

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P Jarho, D W Pate, R Brenneisen, T Järvinen. 1998. Hydroxypropyl-beta-cyclodextrin and its combination with hydroxypropyl-methylcellulose increases aqueous solubility of delta9-tetrahydrocannabinol.. https://doi.org/10.1016/s0024-3205(98)00528-1

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