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PubMed · 11048786

Latitude-correlated genetic polymorphisms: selection or gene flow?

B M Ciminelli·C Jodice·R Scozzari·R M Corbo·M Nahum·F Pompei·S A Santachiara-Benerecetti·C Santolamazza·G P Morpurgo·G Modiano
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Abstract

Latitude-correlated polymorphisms can be due to either selection-driven evolution or gene flow. To discriminate between them, we propose an approach that studies subpopulations springing from a single population that have lived for generations at different latitudes and have had a low genetic admixture. These requirements are fulfilled to a large extent by Ashkenazi and Sephardi Jews. The original population lived at a latitude of 35 degrees N, where the Sephardis still live. The Ashkenazis, however, moved to a latitude of 50 degrees N, starting about 10 centuries ago. The present study examines 3 latitude-correlated polymorphisms: PGP, PGM1, and AHSG. We found that PGP*2 and AHSG*2 alleles most likely underwent selection-driven evolution, but that PGM1*ts allele was not similarly affected. Since temperature might have been considered a reasonable selective factor, we also studied a population living at >800 m above sea level from Aosta Valley (Italy).

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AltitudeBlood ProteinsDiscriminant AnalysisEmigration and ImmigrationGene FrequencyGeographyHaplotypesHumansItalyJewsPhenotypePhosphoglucomutasePhosphoric Monoester HydrolasesPolymorphism, GeneticSelection, GeneticTemperaturealpha-2-HS-GlycoproteinComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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B M Ciminelli, C Jodice, R Scozzari, R M Corbo, M Nahum, F Pompei, S A Santachiara-Benerecetti, C Santolamazza, G P Morpurgo, G Modiano. 2000. Latitude-correlated genetic polymorphisms: selection or gene flow?. https://pubmed.ncbi.nlm.nih.gov/11048786/

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