Analytical performance of polymer-based microfluidic devices fabricated by computer numerical controlled machining.

Justin S Mecomber; Apryll M Stalcup; Doug Hurd; H Brian Halsall; William R Heineman; Carl J Seliskar; Kenneth R Wehmeyer; Patrick A Limbach

doi:10.1021/ac051523y

PubMed · 16448071

Analytical performance of polymer-based microfluidic devices fabricated by computer numerical controlled machining.

Justin S Mecomber·Apryll M Stalcup·Doug Hurd·H Brian Halsall·William R Heineman·Carl J Seliskar·Kenneth R Wehmeyer·Patrick A Limbach

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Abstract

A study comparing the electrophoretic separation performance attainable from microchips molded by masters fabricated using conventional CNC machining techniques with commercial microchips, wire imprinted microchips, and microchips from LIGA molding devices is presented. An electrophoresis-based detection system using fluorescence microscopy was used to determine the analytical utility of these microchips. The separation performance of CNC microchips was comparable to commercially available microchips as well as those fabricated from LIGA masters. The important feature of the CNC machined masters is that they have rapid design-to-device times using routinely available machining tools. This low-cost prototyping approach provides a new entry point for researchers interested in thermoplastic microchips and can accelerate the development of polymer-based lab-on-a-chip devices.

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Computer-Aided Design Image Processing, Computer-Assisted Microfluidic Analytical Techniques Polymers Sensitivity and Specificity Time Factors Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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Justin S Mecomber, Apryll M Stalcup, Doug Hurd, H Brian Halsall, William R Heineman, Carl J Seliskar, Kenneth R Wehmeyer, Patrick A Limbach. 2006-02-01. Analytical performance of polymer-based microfluidic devices fabricated by computer numerical controlled machining.. https://doi.org/10.1021/ac051523y

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