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PubMed · 16459619

Bioinert solution-cross-linked hydrogen-bonded multilayers on colloidal particles.

Sung Yun Yang·Daeyeon Lee·Robert E Cohen·Michael F Rubner
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Abstract

Bioinert polyelectrolyte multilayers comprised of poly(acrylic acid) and polyacrylamide were deposited on colloidal particles (1.7 microm in diameter) at low pH conditions by layer-by-layer assembly using hydrogen-bonding interactions. The multilayer films were coated uniformly on the colloidal particles without causing any flocculation of the colloids, and the deposited films were subsequently cross-linked by a single treatment of a carbodiimide aqueous solution. The lightly cross-linked multilayer films show excellent stability at physiological conditions (pH 7.4, phosphate-buffered saline), whereas untreated multilayer films dissolved. The multilayer-coated surfaces, both on flat substrates and on colloidal particles, exhibit excellent resistance toward mammalian cell adhesion. With this new solution-based cross-linking method, bioinert H-bonded multilayer coatings offer potential for biomedical applications.

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Acrylic ResinsCoated Materials, BiocompatibleColloidsElectrolytesHydrogen BondingHydrogen-Ion ConcentrationMembranes, ArtificialParticle SizeSolutionsWaterPolyacrylamidesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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Sung Yun Yang, Daeyeon Lee, Robert E Cohen, Michael F Rubner. 2004-07-06. Bioinert solution-cross-linked hydrogen-bonded multilayers on colloidal particles.. https://doi.org/10.1021/la0490442

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