PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 16791040

Flat-panel volume computed tomography for cochlear implant electrode array examination in isolated temporal bone specimens.

Soenke H Bartling·Rajiv Gupta·Attila Torkos·Christian Dullin·Grabbe Eckhardt·Thomas Lenarz·Hartmut Becker·Timo Stöver
View original source ↗Export metadata ↓

Abstract

HYPOTHESIS: Flat-panel based volume computed tomography could improve cochlear implant electrode evaluation in comparison with multislice computed tomography. BACKGROUND: Flat-panel based volume computed tomography offers higher spatial resolution and less metal artifacts than multislice computed tomography. Both characteristics could improve the evaluation of challenging but important questions in cochlear implantation assessment, such as an exact imaging of cochlea, osseous spiral lamina, electrode array position, and single electrode contacts. These questions are not currently fully answered by multislice computed tomography. METHODS: Four isolated temporal bone specimens were scanned in a current multislice computed tomography scanner and in two experimental flat-panel based volume computed tomography scanners before and after cochlea implantation. To compare flat-panel based volume computed tomography and multislice computed tomography, four features were rated according to the following criteria: 1) visibility of the cochlea; 2) visibility of the osseous spiral lamina; 3) discernibility of individual electrode contacts; and 4) the ability to determine the electrode array position relative to scala tympani and scala vestibuli. Layer-by-layer microgrinding pictures were used as the ground truth for verification of imaging findings. RESULTS: Flat-panel based volume computed tomography was superior to multislice computed tomography in all four features rated. The cochlea and facial nerve canal were much better delineated in flat-panel based volume computed tomography. The osseous spiral lamina and single electrode contacts were only visible in flat-panel based volume computed tomography. Assessment of implant position with regard to the cochlear spaces was considerably improved by flat-panel based volume computed tomography. CONCLUSION: Cochlear implantation assessment could be improved by flat-panel based volume computed tomography and, therefore, would be highly beneficial for cochlea implantation research and for clinical evaluation. However, these first results were shown by scanning isolated temporal bone specimens; scanning whole human skull bases might be more challenging.

Explore related subjects

ArtifactsCochleaCochlear ImplantsElectric StimulationFacial NerveHearing LossHumansSpiral LaminaTemporal BoneTomography, X-Ray ComputedComparative StudyJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Soenke H Bartling, Rajiv Gupta, Attila Torkos, Christian Dullin, Grabbe Eckhardt, Thomas Lenarz, Hartmut Becker, Timo Stöver. 2006. Flat-panel volume computed tomography for cochlear implant electrode array examination in isolated temporal bone specimens.. https://doi.org/10.1097/01.mao.0000194816.15298.50

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2026

Striping artifact removal in VisiumHD data through nuclear counts modeling.

MOTIVATION: 10x Genomics VisiumHD enables spatial transcriptomics at 2 µm × 2 µm resolution but exhibits slide-specific, non-periodic striping artifacts due to lane-width variability. These multiplicative row/column effects distort bin total counts and can bias downstream analyses. The state-of-the-art destriping approach is the normalization procedure used as a preprocessing step in bin2cell; it applies sequential high-quantile row- then column-wise normalization, which is asymmetric and can introduce edge effects/macro-stripes and distortions of large-scale total-count structure. RESULTS: We propose a statistical destriping approach that leverages nuclei segmentation from the co-registered H&E image. Assuming transcript abundance is constant within each nucleus, we model bin counts with a negative binomial distribution whose mean is a product of a nucleus-specific concentration and row- and column-specific stripe-factors reflecting lane-width variation. We fit all parameters in a generalized linear modeling framework with cross-validated regularization on stripe-factors and iterative dispersion estimation, and use the fitted parameters to correct the observed counts into a destriped image. On synthetic data with known ground truth, our method improves stripe-factor estimation accuracy and reduces error in corrected counts relative to bin2cell and bin2cell-derived baselines. Across four public VisiumHD slides, it consistently lowers striping intensity while substantially better preserving biological signal present in the large-scale global count structure and avoiding the artifacts introduced by other methods. AVAILABILITY AND IMPLEMENTATION: All source code and links to publicly available data used for this study are available at https://github.com/paolamalsot/destriping-GLM.

Artifacts↗
PubMed2008

Impairment of echocardiographic acoustic window caused by breast implants.

Cosmetic breast implants are increasing in popularity. The presence of a breast implant overlying the anterior mediastinal space as a cause of impairment of the echocardiographic acoustic window has not been described previously. Here, we report three cases with significant impairment of echocardiographic acoustic window caused by breast implants. Clinicians should be aware of this interference and women should be informed of this dilemma before considering this cosmetic surgery.

Artifacts↗