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PubMed · 16851322

Light-responsive polyelectrolyte/gold nanoparticle microcapsules.

Alexandra S Angelatos·Benno Radt·Frank Caruso
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Abstract

We report the preparation and characterization of light-responsive delivery vehicles, microcapsules composed of multiple polyelectrolyte layers and light-absorbing gold nanoparticles. The nanostructured capsules were loaded with macromolecules (fluorescein isothiocyanate-labeled dextran) by exploiting the pH-dependence of the shell permeability, and the encapsulated material was released on demand upon irradiation with short (10 ns) laser pulses in the near-infrared (1064 nm). In addition, the polyelectrolyte multilayer shell was modified with lipids (dilauroylphosphatidylethanolamine) and then functionalized with ligands (monoclonal immunoglobulin G antibodies) for the purposes of enhanced stability and targeted delivery, respectively. We anticipate that these capsules will find application in a range of areas where controlled delivery is desirable.

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CapsulesDrug Delivery SystemsElectrolytesFluorescein-5-isothiocyanateGoldHydrogen-Ion ConcentrationLasersLightLipidsMetal NanoparticlesMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionMicroscopy, FluorescencePermeabilitySpectrophotometry, InfraredJournal ArticleResearch Support, Non-U.S. Gov't

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Alexandra S Angelatos, Benno Radt, Frank Caruso. 2005-02-24. Light-responsive polyelectrolyte/gold nanoparticle microcapsules.. https://doi.org/10.1021/jp045070x

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