Multifunctional polyelectrolyte multilayer films: combining mechanical resistance, biodegradability, and bioactivity.

Aurore Schneider; Constant Vodouhê; Ludovic Richert; Gregory Francius; Erell Le Guen; Pierre Schaaf; Jean-Claude Voegel; Benoît Frisch; Catherine Picart

doi:10.1021/bm060765k

PubMed · 17206799

Multifunctional polyelectrolyte multilayer films: combining mechanical resistance, biodegradability, and bioactivity.

Aurore Schneider·Constant Vodouhê·Ludovic Richert·Gregory Francius·Erell Le Guen·Pierre Schaaf·Jean-Claude Voegel·Benoît Frisch·Catherine Picart

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Abstract

Cross-linked polyelectrolyte multilayer films (CL PEM) have an increased rigidity and are mechanically more resistant than native (e.g., uncrosslinked) films. However, they are still biodegradable, which make them interesting candidates for biomedical applications. In this study, CL PEM films have been explored for their multifunctional properties as (i) mechanically resistant, (ii) biodegradable, and (iii) bioactive films. Toward this end, we investigated drug loading into CL chitosan/hyaluronan (CHI/HA) and poly(L-lysine)/hyaluronan (PLL/HA) films by simple diffusion of the drugs. Sodium diclofenac and paclitaxel were chosen as model drugs and were successfully loaded into the films. The effect of varying the number of layers in the (CHI/HA) films as well as the cross-linker concentration on diclofenac loading were studied. Diclofenac was released from the film in about 10 h. Paclitaxel was also found to diffuse within CL films. Its activity was maintained after loading in the CL films, and cellular viability could be reduced by about 55% over 3 days. Such a simple approach may be applied to other types of cross-linked films and to other drugs. These results prove that it is possible to design multifunctional multilayer films that combine mechanical resistance, biodegradability, and bioactivity properties into a single PEM architecture.

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Adsorption Anti-Inflammatory Agents, Non-Steroidal Biodegradation, Environmental Cell Line, Tumor Chitosan Cross-Linking Reagents Diclofenac Electrolytes Humans Hyaluronic Acid Macromolecular Substances Microscopy, Atomic Force Polylysine Stress, Mechanical Tensile Strength Journal Article Research Support, Non-U.S. Gov't

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Aurore Schneider, Constant Vodouhê, Ludovic Richert, Gregory Francius, Erell Le Guen, Pierre Schaaf, Jean-Claude Voegel, Benoît Frisch, Catherine Picart. 2007. Multifunctional polyelectrolyte multilayer films: combining mechanical resistance, biodegradability, and bioactivity.. https://doi.org/10.1021/bm060765k

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