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PubMed · 3528436

Lung cancer screening: the Mayo program.

R S Fontana·D R Sanderson·L B Woolner·W F Taylor·W E Miller·J R Muhm
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Abstract

The National Cancer Institute has sponsored three randomized controlled trials of screening for early lung cancer in large, high-risk populations to determine whether lung cancer detection can be improved by adding sputum cytological screening every 4 months to chest roentgenography done either yearly or every 4 months; and lung cancer mortality can be significantly reduced by this type of screening program, followed by appropriate treatment. Results of the three trials suggest that sputum cytology alone detects 15% to 20% of lung cancers, almost all of which are squamous cancers with a favorable prognosis; and chest roentgenography may be a more effective test for early-stage lung cancer than previous reports have suggested. Nevertheless, results of the randomized trial conducted at the Mayo Clinic showed that offering both procedures to high-risk outpatients every 4 months conferred no mortality advantage over standard medical practice that included recommended annual testing.

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Clinical Trials as TopicCytodiagnosisHumansLungLung NeoplasmsMass ScreeningRadiographyRandom AllocationRiskSputumClinical TrialComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R S Fontana, D R Sanderson, L B Woolner, W F Taylor, W E Miller, J R Muhm. 1986. Lung cancer screening: the Mayo program.. https://doi.org/10.1097/00043764-198608000-00038

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