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Fully automated sample handling system for liquid chromatography based on pre-column technology and automated cartridge exchange.

M W Nielen·A J Valk·R W Frei·U A Brinkman·P Mussche·R De Nijs·B Ooms·W Smink
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Abstract

The design of an automated cartridge exchange module for on-line sample handling in liquid chromatography is described. When combined with a low-cost purge pump, a solvent selection valve and an auto-sampler, a fully automated sample handling system is obtained. Samples are sorbed on a disposable cartridge packed with 40 micron octyl-bonded silica, purged for clean-up and eluted on-line to the analytical column. Unattended operation of the system is demonstrated for various examples, i.e., the determination of anti-epileptic drugs in serum, an anti-cancer drug in plasma, barbiturates in urine, phenylurea herbicides in river water and caffeine in a soft drink.

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AutoanalysisBeveragesChromatography, LiquidHumansPharmaceutical PreparationsSpectrophotometry, UltravioletWater SupplyJournal ArticleResearch Support, Non-U.S. Gov't

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M W Nielen, A J Valk, R W Frei, U A Brinkman, P Mussche, R De Nijs, B Ooms, W Smink. 1987-04-22. Fully automated sample handling system for liquid chromatography based on pre-column technology and automated cartridge exchange.. https://doi.org/10.1016/s0021-9673(01)94205-0

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