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PubMed · 4032056

First-third ejection fraction: is the first-pass radionuclide method accurate?

R N Pierson·A Yamashina·M I Friedman·N Roistacher
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Abstract

Previous reports have suggested that left ventricular first-third ejection fraction (EF) can be obtained from the left ventricular time-activity curve derived from first-pass radionuclide angiography based on Anger camera data. The validity of this technique was assessed by: a study of beat-to-beat variations in data from 15 patients in which electrocardiographic data were simultaneously recorded, and a computer simulation incorporating the application of Poisson statistics to appropriate count rate data. The results of patients studies showed no consistent trend in any first-third parameter obtained from consecutive beats in individual subjects, and unacceptably high statistical uncertainty in the calculation of the first-third ejection fraction. The weighted standard deviation of the first-third ejection fraction in each of 15 patients studied averaged 7.5 EF units, while first-third ejection fraction averaged 22.9 EF units. The relative error averaged 32%. The computer simulation indicated a high relative error of 47% associated with the first-third ejection fraction at typical end-diastolic count rates of 200 per frame from 1,000 computer Poisson randomizations of an appropriate analog volume curve. The results render the first-pass radiocardiographic method invalid for determining first-third ejection fraction.

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AdultAgedCardiac OutputComputersCoronary DiseaseElectrocardiographyFemaleHeartHeart DiseasesHeart Valve DiseasesHemodynamicsHumansMaleMiddle AgedModels, CardiovascularProbabilityRadionuclide ImagingStroke VolumeJournal Article

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BibTeXRIS

R N Pierson, A Yamashina, M I Friedman, N Roistacher. 1985. First-third ejection fraction: is the first-pass radionuclide method accurate?. https://pubmed.ncbi.nlm.nih.gov/4032056/

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