PubMed · 4244680
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E Ostergaard. 1969. Oral anticonception. Side effects and risks.. https://pubmed.ncbi.nlm.nih.gov/4244680/
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Acne is a multifactorial disease affecting the pilosebaceous follicles. It is a treatable condition for which the aims of therapy are to reduce social isolation and to prevent or minimise scarring. Propionibacterium acnes is an anaerobic bacterium strongly implicated in the pathogenesis of acne. A gradual increase in the resistance of P. acnes to many antibiotics has been documented in the last decade, and there is thus a growing need to use either appropriate antibiotics or even change the therapeutic strategy in favour of other regimens, i.e. isotretinoin, antiandrogens. A treatment guide is presented and the side-effects of these regimens are discussed.
Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years.