PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 7133014

[Iron-deficiency and replacement in infancy].

D Schuler·E Kis·L Velkey·I Velkey·K Németh·V Mann
View original source ↗Export metadata ↓

Abstract

The frequency of iron-deficiency anaemia was investigated in 376 children with the aid of serum ferritin determinations. The children, resident in Budapest or Miskolc were 6 months to 3 years old. Marked iron-deficiency (serum ferritin less than 10 micrograms/l) could be demonstrated in 33.8% of the investigated population. The frequency of iron-deficiency was related to the socio-economic and cultural status of the mother, a factor which is thought to influence the feeding habits. In areas where iron-deficiency is frequently detected regular iron-prophylaxis is recommended.

Explore related subjects

Anemia, HypochromicChild, PreschoolFerritinsHumansHungaryInfantInfant Nutritional Physiological PhenomenaIronSocioeconomic FactorsEnglish AbstractJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D Schuler, E Kis, L Velkey, I Velkey, K Németh, V Mann. 1982. [Iron-deficiency and replacement in infancy].. https://pubmed.ncbi.nlm.nih.gov/7133014/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

[Erythropoietin is a novel therapeutic option in the treatment of anemia caused by small cell lung cancer].

Anemia is very common among patients with malignant tumors, due to the disease and chemotherapy. Anemia decreases the patient's quality of life. Erythropoietin therapy is accessible in Hungary for the treatment of chemotherapy-induced anemia in patients suffering from small cell lung cancer. In our case report we present the case of a 62-year-old female small cell lung cancer patient with severe anemia, treated by erythropoietin-beta. The erythropoietin treatment provided the possibility of effective chemo- and radiotherapy. The patient's quality of life greatly improved due to the lack of the symptoms of anemia. The adequate use of erythropoietin is of great help to the physician in the management of small cell lung cancer patients, by improving the quality of life.

Anemia, Hypochromic↗
PubMed2006

Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice.

Patients with deficiency in ferrochelatase (FECH), the last enzyme of the heme biosynthetic pathway, experience a painful type of skin photosensitivity called erythropoietic protoporphyria (EPP), which is caused by the excessive production of protoporphyrin IX (PPIX) by erythrocytes. Controversial results have been reported regarding hematologic status and iron status of patients with EPP. We thoroughly explored these parameters in Fechm1Pas mutant mice of 3 different genetic backgrounds. FECH deficiency induced microcytic hypochromic anemia without ringed sideroblasts, little or no hemolysis, and no erythroid hyperplasia. Serum iron, ferritin, hepcidin mRNA, and Dcytb levels were normal. The homozygous Fechm1Pas mutant involved no tissue iron deficiency but showed a clear-cut redistribution of iron stores from peripheral tissues to the spleen, with a concomitant 2- to 3-fold increase in transferrin expression at the mRNA and the protein levels. Erythrocyte PPIX levels strongly correlated with serum transferrin levels. At all stages of differentiation in our study, transferrin receptor expression in bone marrow erythroid cells in Fech(m1Pas) was normal in mutant mice but not in patients with iron-deficiency anemia. Based on these observations, we suggest that oral iron therapy is not the therapy of choice for patients with EPP and that the PPIX-liver transferrin pathway plays a role in the orchestration of iron distribution between peripheral iron stores, the spleen, and the bone marrow.

Anemia, Hypochromic↗