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PubMed · 7773200

Localized mitochondrial dysfunction in canine myocardial ischemia.

J Marin-Garcia·M J Goldenthal·R Ananthakrishnan·D Mirvis
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Abstract

Effects of myocardial ischemia on mitochondrial enzymes and mitochondrial DNA (mtDNA) were examined using the model of Ameroid constriction of canine cardiac vessels. Endocardium supplied by constricted coronary arteries was found to have significantly lower citrate synthase and complex IV activities compared to values obtained from either epicardium supplied by constricted vessels or endocardium supplied by unconstricted coronary arteries. Neither significant differences in mtDNA copy number nor changes in respiratory complexes I, III and V were detected. These results suggest that highly localized, specific mitochondrial enzyme changes result from chronic myocardial ischemia.

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AnimalsBase SequenceCattleCitrate (si)-SynthaseConstrictionCoronary VesselsDNA PrimersDNA, MitochondrialDogsElectron Transport Complex IVHumansMitochondria, HeartMolecular Sequence DataMyocardial IschemiaNucleic Acid HybridizationPolymerase Chain ReactionSequence HomologyComparative StudyJournal Article

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J Marin-Garcia, M J Goldenthal, R Ananthakrishnan, D Mirvis. 1995. Localized mitochondrial dysfunction in canine myocardial ischemia.. https://pubmed.ncbi.nlm.nih.gov/7773200/

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