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Injectable bone substitute using a hydrophilic polymer.

P Weiss·O Gauthier·J M Bouler·G Grimandi·G Daculsi
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Abstract

We studied a new injectable biomaterial for bone and dental surgery consisting of a hydrophilic polymer as matrix and bioactive calcium phosphate (CaP) ceramics as fillers. This material is composed of complex fluids whose flow is determined by the laws of rheology. We investigated the macromolecular effects on this composite in a tube. The stability of the polymer and the mixture is essential to the production of a ready-to-use injectable biomaterial. These flow properties are necessary to obtain CaP bioactivity in a dental canal or bone defect during percutaneous surgery. Macromolecules provide spaces between CaP ceramic granules and facilitate the role of the biological agents of bone substitution.

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AnimalsBiocompatible MaterialsBone SubstitutesCalcium PhosphatesFemurImplants, ExperimentalInjectionsLactoseMaterials TestingMethylcelluloseOxazinesRabbitsRheologyViscosityJournal ArticleResearch Support, Non-U.S. Gov't

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P Weiss, O Gauthier, J M Bouler, G Grimandi, G Daculsi. 1999. Injectable bone substitute using a hydrophilic polymer.. https://doi.org/10.1016/s8756-3282(99)00146-5

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